GLP-1 Injection Sites: Where and How They're Given

Short answer: GLP-1 medications like semaglutide and tirzepatide are given as a subcutaneous (under-the-skin) injection, typically in the abdomen, thigh, or upper arm. Providers generally recommend rotating between sites each week. This is general information, always follow the specific instructions from your provider and the medication's prescribing information.

Common injection sites

• Abdomen (avoiding a 2-inch area around the navel)
• Front of the thigh
• Back of the upper arm

Why rotating sites matters

Injecting in the same exact spot repeatedly can lead to irritation or changes in the skin and underlying tissue at that site. Rotating between the abdomen, thigh, and arm, and between different spots within each area, week to week is a standard recommendation across GLP-1 medications.

Before you inject

Your provider or pharmacist will walk you through the specific device you're prescribed, pens and delivery systems vary by medication and manufacturer. This page is general background, not instructions for use. Always follow the official instructions that come with your specific prescription.